![]() ![]() In contrast, estrone, cortisone, proline, cystine, 3-ureidopropionic acid, and histidine were associated with Atorvastatin-induced liver toxicity. In another study, 1H NMR-based metabolomics were used to monitor plasma and liver profiles following Atorvastatin treatment. ![]() Atorvastatin restored the levels of ketone bodies, acetoacetate, acetone, and 3-hydroxybutyrate to normal. Protein metabolism was also impacted, thus returning glutamine and glucogenic amino acids to nascent levels. Atorvastatin competitively inhibited HMG-CoA reductase in the liver to decrease cholesterol and increase LDL receptor synthesis thus decreasing LDL-C, an effect consistent with its preventive and therapeutic role in atherosclerosis. Serum metabolomics in the hyperlipidemia hamster model demonstrated that lipid metabolism could be returned to normal and gut microbiota reestablished with metronidazole treatment. Using GC-TOF/MS, increased serum free fatty acids and TC and significantly decreased hyaluronic acid, creatinine, and succinic acid were observed in hyperlipidemic hamsters. ![]() In addition, phenylalanine, tryptophan, glutamic acid, threonine, methionine, and other amino acids were also changed. 1H NMR plasma and liver metabolomics were employed to explore the therapeutic effects of 2′,3′,5′-tria-cetyl-N6-(3-hydroxylaniline) adenosine (WS070117) in hyperlipidemic Syrian golden hamsters. Increased TG, TC, lactate, alanine, and decreased choline-containing metabolites (phosphocholine, PC and glycerophosphocholine) and betaine were observed. WS070117 regulated lipid metabolism and displayed more beneficial effects on plasma and liver indices than Simvastatin. Similar results were obtained in a 1H NMR metabolomic study on hyperlipidemic Syrian golden hamsters treated with cordycepin. Increased glutamine and decreased glucose and glycogen were additionally found in both plasma and liver. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |